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研究用于肺癌和黑色素瘤细胞肺转移的选择性PAK4抑制剂的合成，此选择性PAK4抑制剂的PK研究通过pg电子官网进行

2023-06-28
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1-Compound-55-is-effective-in-the-treatment-of-metastatic-cancer-1.jpg

The p21 activated kinase 4 (PAK4) is serine/threonine protein kinase that is critical for cancer progression. 6-Ethynyl-1H-indole derivative 55 is a potent and selective PAK4 inhibitor (Ki=10.2 nM). Compound 55 is effective in the treatment of metastatic cancer. The pharmacokinetic study of Compound 55 was carried out by Medicilon.

Reference

Peilu Song, et al. Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells. Acta Pharm Sin B. 2022 Jun;12(6):2905-2922. doi: 10.1016/j.apsb.2022.02.029.

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