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搜索结果包含 tumor 的内容

Jul 06,2023
表观遗传修饰,如DNA甲基化,在遗传信息的表达中发挥着重要作用。DNA甲基转移酶维持DNA甲基化,是肿瘤化疗的一个有吸引力的靶点
Epigenetic modification, like DNA methylation, plays a major role in the expression of genetic information. The DNA methyltransferases (DNMTs), maintain DNA methylation, is an attractive target for tu
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表观遗传修饰,如DNA甲基化,在遗传信息的表达中发挥着重要作用。DNA甲基转移酶维持DNA甲基化,是肿瘤化疗的一个有吸引力的靶点
Jul 06,2023
Columbin具有多种药理活性,包括体内抗炎和抗肿瘤活性,此实验中动物研究通过pg电子官网进行
Columbin is an important component isolated from Radix Tinosporae. Columbin possesses many pharmacological activities, including anti-inflammation, and antitumor activity in vivo. The purpose of the p
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Columbin具有多种药理活性,包括体内抗炎和抗肿瘤活性,此实验中动物研究通过pg电子官网进行
Jul 06,2023
PTX-HSN是一种高效纳米系统,具有较高耐受剂量,可将PTX递送至卵巢癌并增强主动肿瘤靶向性。此研究中所有体内实验均通过pg电子官网进行
Paclitaxel-loaded hyaluronan solid nanoemulsions (PTX-HSNs) were successfully fabricated for the delivery of PTX to improve ovarian cancer treatment via active tumor targeting. The in vivo #toxicity,
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PTX-HSN是一种高效纳米系统,具有较高耐受剂量,可将PTX递送至卵巢癌并增强主动肿瘤靶向性。此研究中所有体内实验均通过pg电子官网进行
Jul 06,2023
AD80是一种多激酶抑制剂,在多种肝细胞癌临床前动物模型中具有抗肿瘤活性,AD80在血浆中的含量通过pg电子官网进行LC-MS/MS测定
Liver cancer is the fourth greatest cause of cancer related mortality. AD80 is a multi-kinase inhibitor with anti-tumoral activity across a variety of hepatocellular carcinoma (HCC) preclinical models
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AD80是一种多激酶抑制剂,在多种肝细胞癌临床前动物模型中具有抗肿瘤活性,AD80在血浆中的含量通过pg电子官网进行LC-MS/MS测定
Jul 06,2023
免疫检查点阻断疗法改变了癌症治疗的范式,此研究中通过pg电子官网在23 个同源肿瘤模型中进行了抗PD-1抗体的体内研究
Immune checkpoint blockade therapies have changed the paradigm of cancer therapies. Reseachers performed in vivo screening for anti-PD-1 therapy across 23 syngeneic tumor models and found th
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免疫检查点阻断疗法改变了癌症治疗的范式,此研究中通过pg电子官网在23 个同源肿瘤模型中进行了抗PD-1抗体的体内研究
Jul 05,2023
合成具有体内抗肿瘤活性的强效PD-L1抑制剂,并进行生物学评价和机制研究。PK研究通过pg电子官网进行
PD-1 and PD-L1 have been very successful for the treatment of various tumors, including NSCLC, urothelial cancer, melanoma, head and neck squamous cell cancer, and lymphoma. Researchers identified com
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合成具有体内抗肿瘤活性的强效PD-L1抑制剂,并进行生物学评价和机制研究。PK研究通过pg电子官网进行
Jul 05,2023
研究人员开发了一种高特异性的CDC7抑制剂TAK-931作为临床肿瘤治疗剂,抗肿瘤药效研究通过pg电子官网进行
Cell division cycle 7 (CDC7) plays important roles in DNA replication. Researchers developed a highly specific CDC7 inhibitor, TAK-931, as a clinical cancer therapeutic agent. The antitumor efficacy s
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研究人员开发了一种高特异性的CDC7抑制剂TAK-931作为临床肿瘤治疗剂,抗肿瘤药效研究通过pg电子官网进行
Jun 28,2023
TAK-243是一种有效的泛素激活酶小分子抑制剂,具有体内抗肿瘤功效,通过pg电子官网使用HCC70模型进行
TAK-243 is a potent, mechanism-based small-molecule inhibitor of the ubiquitin activating enzyme (UAE), the primary mammalian E1 enzyme that regulates the ubiquitin conjugation cascade. TAK-243 has UAE-specific antitumor efficacy in vivo. Medicilon perfor
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TAK-243是一种有效的泛素激活酶小分子抑制剂,具有体内抗肿瘤功效,通过pg电子官网使用HCC70模型进行
Jun 28,2023
CAR-T疗法主要针对白血病与恶性淋巴瘤,此研究中构建沉默PD-1的shRNA载体质粒,测序后质粒的鉴定通过pg电子官网进行
Chimeric antigen receptor T cells (CAR-T) immunotherapy has shown promising clinical results in the treatment of leukemia and lymphoma, but the effectiveness is limited for solid tumors. The shRNA vector plasmid that silences PD-1 and preparation of CAR i
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CAR-T疗法主要针对白血病与恶性淋巴瘤,此研究中构建沉默PD-1的shRNA载体质粒,测序后质粒的鉴定通过pg电子官网进行
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